#1 telenovela actress

In Brazil's most successful Clone telenovela I found 3 leading roles played by Pisces: Giovanna Antonelli (leading role) is Pisces, Debora Falabella Pisces - drug-addict Mel. Pisces is often related to the sign of drug addicts and alcoholics. Very suitable role! Leticia Sabotella - another Pisces. All in one telenovela. Debora Falabella played the leading role in Avenida Brazil and Seniorita. Generally, in Clone all leading roles are of water element (Lucas and Said roles are played by actors Cancers)

Telenovelas are about love, therefore water signs take the lead. Especially water is a feminine energy, Cancer is a feminine sign, and men Cancers can play lovers. Among women first is Pisces. 

Giovanna Antonelli had main roles in 4 telenovelas. Debora Falabella played the main role in Brazil Avenue

Pisces Beren Saat was awarded in 2021 Murex D'or - a prestige award in the Arab world as the best actress. The actress had been most highly paid before Fahriye Evcen took the lead. Ask Memnu was her most successful telenovela. The actress participated in 11 telenovelas in the main role.

Demet Ozdemir Pisces has 7 main roles in telenovelas

Scarlett Ortiz Pisces. Main roles in 3 my sisters, Luisa Fernanda, Rafaela, Secret de Amor etc. (more than 10 main roles in telenovellas)

Sara Maldonado Pisces has 12 main roles in telenovellas. Aurora, El huego de la vida, Corazones al limite, La reina der Sur etc.

Tatyana Arngolts  Pisces played in a number of telenovelas with mini-series (8 series)

Adriana Fonseca Pisces played the main role in el Corazon Valiente. 

Aydan Sener Pisces played Feride in Calikusu, main roles in Samanyoli and Fatih-Harbiye 

Nebahat Cehre Pisces played main roles in 4 telenovelas. Yuvamdaki Dusman, Qanli yanvar, Kara Para Ask (Black Money Love), Magnificent century (Valide)

Araceli Arambula Pisces - the main hero of La Patrona. 

Christin Fernandes Pisces has played many supporting roles.

I don't know any other sign that would compare to Pisces in the number of main roles played in total. Other signs like Leo, Cancer, Scorpio, and Gemini are two times less. 

Leos are second (Meryem Uzerli, Neslihan Atagul, Elcin Sangu, Angelica Cepeda, Marlene Favela, Paulina Gato)